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Repeated amphetamine use, including Adderall, leads to psychological dependence, as users quickly build tolerance, requiring higher doses to achieve the same effects, which significantly increases addiction risk according to Knapp (1952) in the study Amphetamine and Addiction. The signs of Adderall addiction include increasing doses without medical guidance, obsessive thoughts about the drug, and difficulty reducing use despite personal, social, or physical harm

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These results stand in contrast to a purely dopaminergic reward theory, leading to a better understanding of the neurobiology of nicotine motivation and possibly to improved therapeutic treatments for smoking cessation.

A 65-year-old who quits smoking can expect to gain an average of 1.7 years , while a 75-year-old quitter can add 0.7 years to their life